PUBLICATIONS
OUR PUBLISHED EXPERTISE ON THE APPLICABILITY OF FAK-TARGETED THERAPEUTICS IN MULTIPLE TYPES OF CANCER
BREAST CANCER
Golubovskaya V, Beviglia L, Xu L-H, Earp HS, Craven R, Cance WG. Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. J Biol Chem 2002; 277(41):38978-38987. PMID: 12167618
Lark AL, Livasy CA, Dressler L, Moore DT, Millikan RC, Geradts J, Iacocca M, Cowan D, Little D, Craven RJ, Cance WG. High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype. Mod Pathol 2005; 18:1289-1294. PMID: 15861214
Golubovskaya VM, Zheng M, Zhang L, Li J-L, Cance WG. The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis. BMC Cancer 2009; 12(9):280. PMID: 19671193
Golubovskaya VM, Ylagan L, Miller A, Hughes M, Wilson J, Wang D, Brese E, Bshara W, Edge S, Morrison C, Cance, WG. High focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype. BMC Cancer October 2014; 14(1): 769. PMID: 25326692
COLORECTAL CANCER
Lik Hang Lee, Lindy Davis, Lourdes Ylagan, Angela R Omilian, Kristopher Attwood,
Canan Firat, Jinru Shia, Philip B Paty, William G Cance. Identification of a Subset of Stage Journal of the National Cancer Institute
https://doi.org/10.1093/jnci/djac023
Lark AL, Livasy C, Calvo B, Caskey L, Moore DT, Yang X-H, Cance WG. Overexpression of focal adhesion kinase (FAK) in primary colorectal carcinomas and colorectal liver metastases: Immunohistochemistry and real-time PCR analyses. Clin Cancer Res 2003; 9(1):215-222. PMID: 12538472
Heffler M, Golubovskaya VM, Bullard Dunn K, Cance W. Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy. Cancer Biol Ther 2013; 14(8): 761- 772. PMID: 23792569
LUNG CANCER
Dy G, Golubovskaya V, Ylagan L, Pokharel S, Bshara W, Brese E, Morrison C, Cance WG, Miller A. The prognostic significance of focal adhesion kinase (FAK) expression in stage I non-small cell lung cancer. J Thorac Oncol 2014:9:1278-1284. PMID: 25122425
Zhang H, Shao H, Golubovskaya V, Chen H, Cance WG, Adjei A, Dy G. Efficacy of focal adhesion kinase (FAK) inhibition in non-small cell lung cancer with oncogenically-activated MAPK pathways. Br J Cancer. 2016; 115(2): 203-11. PMID: 2733608.
MELANOMA
Smith CS, Golubovskaya VM, Peck E, Xu L-H, Monia BP, Yang, X, Cance WG. Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines. Melanoma Res 2005; 15(5):357-362. PMID: 16179862
Ucar DA, Kurenova E, Garrett TJ, Cance WG, Nyberg C, Cox A, Massoli N, Ostrov DA, Lawrence N, Sebti SM, Zajac-Kaye M, Hochwald SN. Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth. Cell Cycle 2012; 11(17): 3250-3259. PMID: 22894899
Kurenova E, Ucar D, Liao J, Yemma M, Gogate P, Bshara W, Sunar U, Seshadri M, Hochwald S, Cance WG. A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells. Cell Cycle 2014; 13 (16): 2542-2553. PMID: 25486195
GLIOBLASTOMA
Golubovskaya V, Huang G, Baotran H, Yemma M, Morrison C, Lee J, Eliceiri B, Cance WG. Pharmacological blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide. Mol Cancer Ther 2013; 12(2): 162 - 172. PMID: 23243059
SARCOMA
Owens LV, Weiner, T Xu L, Cance WG. Antisense to the focal adhesion kinase gene disrupts human sarcoma growth and adhesion. Surg Forum 1994; 45:501-503.
THYROID CANCER
Owens LV, Xu L-H, Dent GA, Yang X-H, Sturge GC, Craven RJ, Cance WG. Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer. Ann Surg Oncol 1996; 3(1):100-105. PMID: 8770310
O’Brien S, Golubovskaya VM, Conroy J, Liu S, Wang D, Liu B, Cance, WG. FAK inhibition with small molecule inhibitor Y15 decreased viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics. Oncotarget 2014; 5(17): 7945-7959. PMID: 25277205.
OVARIAN CANCER
Judson PL, He X, Cance WG, Van Le L. Over-expression of focal adhesion kinase a protein tyrosine kinase in ovarian carcinoma. Cancer 1999; 86(8):1551-1556. PMID: 10526262
NEUROBLASTOMA
Beierle EA, Trujillo A, Nagaram A, Golubovskaya VM, Cance WG, Kurenova EV. TAE226 inhibits human neuroblastoma cell survival. Cancer Invest 2008; 26(2):145-151. PMID: 18259944
Beierle EA, Massoll NA, Hartwich J, Kurenova EV, Golubovskaya VM, Cance WG, McGrady P, London WB.: Focal adhesion kinase expression in human neuroblastoma: Immunohistochemical and real-time PCR analyses. Clin Cancer Res 2008; 14(11):3299-3305. PMID: 18519756
Beierle EA, Trujillo A, Kurenova EV, Cance WG, Golubovskaya VM. Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines. Mol Carcinog 2010; 49(3):224-234. PMID: 19885861
Beierle EA, Ma X, Stewart J, Nyberg C, Trujillo A, Cance WG, Golubovskaya VM. Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma. Cell Cycle 2010; 9(5)1005-1015. PMID: 20160475
Stewart JE, Ma X, Megison M, Nabers H, Cance WG, Kurenova EV, Beirele EA. Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma. Mol Carcinog. 2013 July 19. [Epub ahead of print]. PMID: 23868727
PANCREATIC CANCER
Liu W, Bloom DA, Cance WG, Kurenova EV, Golubovskaya VM, Hochwald SN. FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis 2008; 29(6)1096-1107.PMID: 18263593
Hochwald SN, Nyberg C, Zheng M, Zheng D, Wood C, Massoll NA, Magis A, Ostrov D, Cance WG, Golubovskaya V. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle 2009; 8(15):2435-2443. PMID: 19571674
Zheng D, Golubovskaya V, Kurenova E, Wood C, Massoll NA, Ostrov D, Cance WG, Hochwald SN. A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts. Mol Carcinog 2010; 49(2):200-209. PMID: 19885860
Kurenova E, Liao J, He DH, Hunt D, Yemma M, Bshara W, Seshadri M, Cance WG. The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth. Oncotarget 2013; 4 (10): 1632-1646. PMID: 24142503
Gogate P, Kurenova E, Ethirajan M, Liao J, Yemma M, Sen A, Pandey R, Cance WG. Targeting the C-terminal focal adhesion kinase scaffold in pancreatic cancer. Cancer Lett Jul 2014. [E-pub ahead of print]. PMID: 25067788